ZFIN ID: ZDB-PUB-080512-8
Zebrafish as a new animal model for movement disorders
Flinn, L., Bretaud, S., Lo, C., Ingham, P.W., and Bandmann, O.
Date: 2008
Source: Journal of neurochemistry   106(5): 1991-1997 (Review)
Registered Authors: Bandmann, Oliver, Ingham, Philip
Keywords: none
MeSH Terms:
  • Animals
  • Antiparkinson Agents/pharmacology*
  • Disease Models, Animal*
  • Drug Evaluation, Preclinical
  • Genetic Predisposition to Disease/genetics
  • Huntington Disease/drug therapy
  • Huntington Disease/genetics*
  • Huntington Disease/physiopathology
  • Movement Disorders/drug therapy
  • Movement Disorders/genetics*
  • Movement Disorders/physiopathology
  • Mutation/genetics
  • Parkinson Disease/drug therapy
  • Parkinson Disease/genetics*
  • Parkinson Disease/physiopathology
  • Zebrafish/genetics*
  • Zebrafish/metabolism
PubMed: 18466340 Full text @ J. Neurochem.
The zebrafish, long recognised as a model organism for the analysis of basic developmental processes, is now also emerging as an alternative animal model for human diseases. This review will first provide an overview of the particular characteristics of zebrafish in general and their dopaminergic nervous system in particular. We will then summarize all work undertaken so far to establish zebrafish as a new animal model for movement disorders and will finally emphasize its particular strength - amenability to high-throughput in vivo drug screening.