PUBLICATION
Two types of mineral-related matrix vesicles in the bone mineralization of zebrafish
- Authors
- Yang, L., Zhang, Y., and Cui, F.Z.
- ID
- ZDB-PUB-080512-2
- Date
- 2007
- Source
- Biomedical materials (Bristol, England) 2(1): 21-25 (Journal)
- Registered Authors
- Cui, Fu-zhai, Zhang, Yu
- Keywords
- none
- MeSH Terms
-
- Animals
- Bone and Bones/physiology*
- Bone and Bones/ultrastructure*
- Calcification, Physiologic/physiology*
- Extracellular Matrix/physiology
- Extracellular Matrix/ultrastructure
- Transport Vesicles/physiology*
- Transport Vesicles/ultrastructure*
- Zebrafish/anatomy & histology*
- Zebrafish/physiology*
- PubMed
- 18458429 Full text @ Biomed. Mater.
Citation
Yang, L., Zhang, Y., and Cui, F.Z. (2007) Two types of mineral-related matrix vesicles in the bone mineralization of zebrafish. Biomedical materials (Bristol, England). 2(1):21-25.
Abstract
Two types of mineral-related matrix vesicle, multivesicular body (MVB) and monovesicle, were detected in the skeletal bone of zebrafish. Transmission electron microscopy and energy dispersive spectroscopy (EDS) analyses of the vesicular inclusions reveal that both types of vesicles contain calcium and phosphorus, suggesting that these vesicles may be involved in mineral ion delivery for the bone mineralization of zebrafish. However, their size and substructure are quite different. Monovesicles, whose diameter ranges from 100 nm to 550 nm, are similar to the previously reported normal matrix vesicles, while MVBs have a larger size of 700-1000 nm in nominal diameter and possess a substructure that is composed of smaller vesicles with their average size around 100 nm. The presence of mineral-related MVBs, which is first identified in zebrafish bone, indicates that the mineralization-associated transportation process of mineral ions is more complicated than is ordinarily imagined.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping