ZFIN ID: ZDB-PUB-080429-2
Use of zebrafish models for the analysis of human disease
Zhu, H., and Zon, L.I.
Date: 2002
Source: Current protocols in human genetics   Chapter 15: Unit 15.3 (Chapter)
Registered Authors: Zon, Leonard I.
Keywords: none
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Cation Transport Proteins/genetics
  • Cation Transport Proteins/metabolism
  • Disease Models, Animal*
  • Gene Targeting
  • Genetic Engineering/methods
  • Genetic Testing
  • Genetics, Medical
  • Humans
  • Iron/metabolism
  • Mutagenesis
  • Oligonucleotides, Antisense/genetics
  • Zebrafish/genetics*
  • Zebrafish/metabolism
PubMed: 18428328 Full text @ Curr. Protoc. Hum. Genet.
The zebrafish has emerged as a powerful animal model for human diseases. While it has long informed us about the biology of early development, it has recently come into favor for the investigation of clinically relevant problems. Genes conserved from fish to humans can be rapidly analyzed using the zebrafish embryo in what is essentially a transparent in vivo assay. This unit describes methodologies including genetic screening, targeted knockdowns, ectopic overexpression, and transgenesis.