PUBLICATION

Clearing the path for germ cells

Authors
Knaut, H., and Schier, A.F.
ID
ZDB-PUB-080309-7
Date
2008
Source
Cell   132(3): 337-339 (Journal)
Registered Authors
Knaut, Holger, Schier, Alexander
Keywords
none
MeSH Terms
  • Animals
  • Cell Movement*
  • Embryo, Nonmammalian/metabolism
  • Germ Cells/cytology*
  • Models, Biological
  • Zebrafish/embryology
PubMed
18267065 Full text @ Cell
Abstract
The chemokine SDF-1a and its receptor CXCR4b guide germ cell migration in zebrafish by activating downstream signaling events. Boldajipour et al. (2008) now report that a second SDF-1a receptor, CXCR7, is also required for guided migration but does not function as a signaling receptor, and instead sequesters SDF-1a. These results highlight the importance of ligand clearance during guided cell migration.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping