|ZFIN ID: ZDB-PUB-080309-7|
Clearing the path for germ cells
Knaut, H., and Schier, A.F.
|Source:||Cell 132(3): 337-339 (Journal)|
|Registered Authors:||Knaut, Holger, Schier, Alexander|
|PubMed:||18267065 Full text @ Cell|
Knaut, H., and Schier, A.F. (2008) Clearing the path for germ cells. Cell. 132(3):337-339.
ABSTRACTThe chemokine SDF-1a and its receptor CXCR4b guide germ cell migration in zebrafish by activating downstream signaling events. Boldajipour et al. (2008) now report that a second SDF-1a receptor, CXCR7, is also required for guided migration but does not function as a signaling receptor, and instead sequesters SDF-1a. These results highlight the importance of ligand clearance during guided cell migration.
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