ZFIN ID: ZDB-PUB-080309-7
Clearing the path for germ cells
Knaut, H., and Schier, A.F.
Date: 2008
Source: Cell   132(3): 337-339 (Journal)
Registered Authors: Knaut, Holger, Schier, Alexander
Keywords: none
MeSH Terms:
  • Animals
  • Cell Movement*
  • Embryo, Nonmammalian/metabolism
  • Germ Cells/cytology*
  • Models, Biological
  • Zebrafish/embryology
PubMed: 18267065 Full text @ Cell
ABSTRACT
The chemokine SDF-1a and its receptor CXCR4b guide germ cell migration in zebrafish by activating downstream signaling events. Boldajipour et al. (2008) now report that a second SDF-1a receptor, CXCR7, is also required for guided migration but does not function as a signaling receptor, and instead sequesters SDF-1a. These results highlight the importance of ligand clearance during guided cell migration.
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