PUBLICATION
Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning
- Authors
- Freisinger, C.M., Schneider, I., Westfall, T.A., and Slusarski, D.C.
- ID
- ZDB-PUB-080218-5
- Date
- 2008
- Source
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences 363(1495): 1377-1385 (Journal)
- Registered Authors
- Slusarski, Diane C.
- Keywords
- calcium, Wnt, beta-catenin, zebrafish, dorsal-ventral axis, left-right patterning
- MeSH Terms
-
- Animals
- Body Patterning/physiology*
- Calcium/metabolism*
- Models, Biological*
- Signal Transduction/physiology*
- Vertebrates/physiology*
- PubMed
- 18198152 Full text @ Phil. Trans. Roy. Soc. Lond., Series B
Citation
Freisinger, C.M., Schneider, I., Westfall, T.A., and Slusarski, D.C. (2008) Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 363(1495):1377-1385.
Abstract
Many aspects of animal development including fertilization as well as organ formation and function are dependent upon the dynamic release of calcium (Ca2+) ions. Although the controlled release and/or accumulation of Ca2+ ions has been extensively studied, how the release dynamics produce a specific biological output in embryonic development is less clear. We will briefly summarize Ca2+ sources, highlight data on endogenous Ca2+ release in vertebrate embryos relevant to body plan formation and cell movement, and integrate pharmacological and molecular-genetic studies to lend insight into the signalling pathways involved. Finally, based on in vivo imaging in zebrafish genetic mutants, we will put forward the model that distinct Ca2+ release dynamics lead to antagonism of the developmentally important Wnt/beta-catenin signalling pathway, while sustained Ca2+ release modulates cell polarization or directed migration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping