ZFIN ID: ZDB-PUB-080209-6
Rod progenitor cells in the mature zebrafish retina
Morris, A.C., Scholz, T., and Fadool, J.M.
Date: 2008
Source: Advances in experimental medicine and biology   613(1): 361-368 (Chapter)
Registered Authors: Fadool, James M.
Keywords: none
MeSH Terms:
  • Animals
  • Models, Biological
  • Retina/cytology*
  • Retinal Rod Photoreceptor Cells/cytology*
  • Stem Cells/cytology*
  • Zebrafish/physiology*
PubMed: 18188965 Full text @ Adv. Exp. Med. Biol.
The zebrafish is an excellent model organism in which to study the retina's response to photoreceptor degeneration and/or acute injury. While much has been learned about the retinal stem and progenitor cells that mediate the damage response, several questions remain that cannot be addressed by acute models of injury. The development of genetic models, such as the XOPS-mCFP transgenic line, should further efforts to understand the nature of the signals that promote rod progenitor proliferation and differentiation following photoreceptor loss. This in turn may help to refine future approaches in higher vertebrates aimed at enhancing retinal progenitor cell activity for therapeutic purposes.