ZFIN ID: ZDB-PUB-071118-28
Gore et al. reply
Gore, A.V., Cheong, A., Gilligan, P.C., and Sampath, K.
Date: 2007
Source: Nature   450(7167): E2-E4 (Journal)
Registered Authors: Cheong, Albert, Gilligan, Patrick, Gore, Aniket, Sampath, Karuna
Keywords: none
MeSH Terms: none
PubMed: none Full text @ Nature
Replying to: J. T. Bennett et al. 450, doi: 10.1038/nature06314 (2007) We presented several lines of evidence indicating that dorso-ventral asymmetry is apparent in zebrafish embryos by cleavage stages, one of which showed that injection of three different morpholino oligonucleotides targeting three different squint (sqt) sequences cause severe disruption in dorsal structures. We concluded that the dorsal axis is evident by the 4-cell stage, and suggested that maternal Sqt and associated factors may function in zebrafish dorsal-axis formation. Bennett et al. challenge our results obtained with morpholino oligonucleotides because they do not find a comparable defect in maternal and zygotic sqt mutants.