PUBLICATION
The optokinetic response in zebrafish and its applications
- Authors
- Huang, Y.Y., and Neuhauss, S.C.
- ID
- ZDB-PUB-071118-24
- Date
- 2008
- Source
- Frontiers in bioscience : a journal and virtual library 13(1): 1899-1916 (Review)
- Registered Authors
- Huang, Melody Ying-Yu, Neuhauss, Stephan
- Keywords
- none
- MeSH Terms
-
- Animals
- Eye/metabolism*
- Eye Movements*
- Humans
- Kinetics
- Mutation
- Ocular Physiological Phenomena*
- Saccades/physiology
- Vertebrates/metabolism
- Vision, Ocular
- Visual Pathways
- Zebrafish
- Zebrafish Proteins/physiology
- PubMed
- 17981678 Full text @ Front. Biosci.
Citation
Huang, Y.Y., and Neuhauss, S.C. (2008) The optokinetic response in zebrafish and its applications. Frontiers in bioscience : a journal and virtual library. 13(1):1899-1916.
Abstract
The optokinetic response (OKR) is a stereotyped eye movement in response to movement in he surround. The OKR serves to stabilize the visual image on the retina, and allows for high resolution vision. Due to its high selection value, all vertebrates display this basic behavior. Here, we review the properties of the OKR with a focus on the zebrafish, including methodological aspects of measuring eye movements in small larvae. The genetic amenabilities of the zebrafish model permit the use of this reflexive behavior in genetic screens. Such approaches have led to the isolation of mutant strains with specific defects in the visual pathway. In addition to the use of the OKR as a screening assay, mutations with characteristic abnormalities in the execution of this behavior will enable the analysis of sensory-motor control in great detail. A case in point is the belladonna mutation, where an axonal misrouting effect at the optic chiasm leads to a reversed OKR with a number of interesting properties.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping