|ZFIN ID: ZDB-PUB-071009-16|
Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord
Mann, C.J., Osborn, D.P., and Hughes, S.M.
|Source:||Gene expression patterns : GEP 7(8): 827-836 (Journal)|
|Registered Authors:||Hughes, Simon M., Osborn, Dan|
|Keywords:||Muscle, Adaxial, Zebrafish, Vestigial-like, Transcription enhancer factor, TEAD domain, Vgl, Skeletal muscle, VITO, Vestigial, Notochord, TEAD, Tef, Scalloped, Rhombomere, Eye; Epiphysis, Somite, Gene expression, Floatinghead, Cyclopamine, Smoothened, After eight, Fused somites, Danio rerio|
|PubMed:||17916448 Full text @ Gene Expr. Patterns|
Mann, C.J., Osborn, D.P., and Hughes, S.M. (2007) Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord. Gene expression patterns : GEP. 7(8):827-836.
ABSTRACTThe vestigial gene has been shown to control skeletal muscle formation in Drosophila and the related Vestigial-like 2 (Vgl-2) protein plays a similar role in mice. Vgl-family proteins are thought to regulate tissue-specific gene expression by binding to members of the broadly expressed Scalloped/Tef/TEAD transcription factor family. Zebrafish have at least four Vgl genes, including two Vgl-2s, and at least three TEAD genes, including two Tead3s. We describe the cloning and expression of one member from each family in the zebrafish. A novel gene, vgl-2b, with closest homology to mouse and human vgl-2, is expressed transiently in nascent notochord and in muscle fibres as they undergo terminal differentiation during somitogenesis. Muscle cells also express a TEAD-3 homologue, a possible partner of Vgl-2b, during myoblast differentiation and early fibre assembly. Tead-3a is also expressed in rhombomeres, eye and epiphysis regions.