PUBLICATION

Signals on the move: chemokine receptors and organogenesis in zebrafish

Authors
Perlin, J.R., and Talbot, W.S.
ID
ZDB-PUB-070827-20
Date
2007
Source
Sci. STKE   2007(400): pe45 (Journal)
Registered Authors
Perlin, Julie, Talbot, William S.
Keywords
none
MeSH Terms
  • Animals
  • Models, Biological
  • Organogenesis/physiology*
  • Receptors, CXCR4/metabolism
  • Receptors, CXCR4/physiology
  • Receptors, Chemokine/metabolism*
  • Receptors, Chemokine/physiology
  • Signal Transduction*
  • Zebrafish/embryology
  • Zebrafish/metabolism*
  • Zebrafish Proteins/metabolism
  • Zebrafish Proteins/physiology
PubMed
17712137 Full text @ Sci. STKE
Abstract
The chemokine SDF1 (stromal cell-derived factor 1) directs cell migration in many different contexts, ranging from embryogenesis to inflammation. SDF1a is the guidance cue for the zebrafish lateral line primordium, a tissue that moves along the flank of the embryo and deposits cells that form mechanosensory organs. The SDF1a receptor CXCR4b acts in cells at the leading edge of the primordium to direct its migration. Two new studies show that a second SDF1 receptor, CXCR7, is required only in the trailing cells of the primordium, and they explore how these two receptors orchestrate migration of the primordium. CXCR4b and CXCR7 are expressed in complementary domains, possibly through mutual repression in which each receptor inhibits expression of the other. These studies illustrate how the entire primordium can respond to a single signal, yet generate cell type-specific responses by using different receptors.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping