PUBLICATION
Curcumin affects development of zebrafish embryo
- Authors
- Wu, J.Y., Lin, C.Y., Lin, T.W., Ken, C.F., and Wen, Y.D.
- ID
- ZDB-PUB-070711-23
- Date
- 2007
- Source
- Biological & pharmaceutical bulletin 30(7): 1336-1339 (Journal)
- Registered Authors
- Ken, Chuian-Fu
- Keywords
- curcumin, embryotoxicity, zebrafish
- MeSH Terms
-
- Abnormalities, Drug-Induced*
- Animals
- Curcumin/pharmacokinetics
- Curcumin/toxicity*
- Dose-Response Relationship, Drug
- Embryo, Nonmammalian/drug effects*
- Embryo, Nonmammalian/metabolism
- Female
- Larva/drug effects
- Larva/metabolism
- Lethal Dose 50
- Zebrafish/embryology*
- PubMed
- 17603177 Full text @ Biol. Pharm. Bull.
Citation
Wu, J.Y., Lin, C.Y., Lin, T.W., Ken, C.F., and Wen, Y.D. (2007) Curcumin affects development of zebrafish embryo. Biological & pharmaceutical bulletin. 30(7):1336-1339.
Abstract
Embryotoxic and teratogenic effects of curcumin on the development of zebrafish embryo were investi-gated in this study. The LD(50) values of curcumin (24-h incubation) were estimated at 7.5 muM and 5 muM for embryos and larvae, respectively. The developmental defects caused by curcumin treatments include bent or hook-like tails, spinal column curving, edema in pericardial sac, retarded yolk sac resorption, and shorter body length. In curcumin-treated larvae, fluorescence signals of curcumin were found in edamae sac and some skin cells. Together, these results indicate that zebrafish are suitable model organisms to study the toxic effects of curcumin.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping