PUBLICATION

Phenotype ontologies: the bridge between genomics and evolution

Authors
Mabee, P.M., Ashburner, M., Cronk, Q., Gkoutos, G.V., Haendel, M., Segerdell, E., Mungall, C., and Westerfield, M.
ID
ZDB-PUB-070601-2
Date
2007
Source
Trends in Ecology & Evolution   22(7): 345-350 (Journal)
Registered Authors
Haendel, Melissa A., Mabee, Paula M., Segerdell, Erik, Westerfield, Monte
Keywords
none
MeSH Terms
  • Anatomy
  • Animals
  • Biological Evolution*
  • Databases, Factual*
  • Genomics*
  • Genotype
  • Humans
  • Phenotype
PubMed
17416439 Full text @ Trends Ecol. Evol.
Abstract
Understanding the developmental and genetic underpinnings of particular evolutionary changes has been hindered by inadequate databases of evolutionary anatomy and by the lack of a computational approach to identify underlying candidate genes and regulators. By contrast, model organism studies have been enhanced by ontologies shared among genomic databases. Here, we suggest that evolutionary and genomics databases can be developed to exchange and use information through shared phenotype and anatomy ontologies. This would facilitate computing on evolutionary questions pertaining to the genetic basis of evolutionary change, the genetic and developmental bases of correlated characters and independent evolution, biomedical parallels to evolutionary change, and the ecological and paleontological correlates of particular types of change in genes, gene networks and developmental pathways.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes