Sensorimotor gating in larval zebrafish
- Burgess, H.A., and Granato, M.
- The Journal of neuroscience : the official journal of the Society for Neuroscience 27(18): 4984-4994 (Journal)
- Registered Authors
- Burgess, Harold, Granato, Michael
- zebrafish, prepulse inhibition, behavior, sensorimotor gating, dopamine, startle response
- MeSH Terms
- Acoustic Stimulation/methods
- Psychomotor Performance/physiology*
- Reaction Time/physiology*
- Reflex, Startle/physiology*
- 17475807 Full text @ J. Neurosci.
Burgess, H.A., and Granato, M. (2007) Sensorimotor gating in larval zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(18):4984-4994.
Control of behavior in the natural environment where sensory stimuli are abundant requires superfluous information to be ignored. In part, this is achieved through selective transmission, or gating of signals to motor systems. A quantitative and clinically important measure of sensorimotor gating is prepulse inhibition (PPI) of the startle response, impairments in which have been demonstrated in several neuropsychiatric disorders, including schizophrenia. Here, we show for the first time that the acoustic startle response in zebrafish larvae is modulated by weak prepulses in a manner similar to mammalian PPI. We demonstrate that, like in mammals, antipsychotic drugs can suppress disruptions in zebrafish PPI induced by dopamine agonists. Because genetic factors underlying PPI are not well understood, we performed a screen and isolated mutant lines with reduced PPI. Analysis of Ophelia mutants demonstrates that they have normal sensory acuity and startle performance, but reduced PPI, suggesting that Ophelia is critical for central processing of sensory information. Thus, our results provide the first evidence for sensorimotor gating in larval zebrafish and report on the first unbiased screen to identify genes regulating this process.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes