PUBLICATION
Effects of Nicotine on Growth And Development in Larval Zebrafish
- Authors
- Parker, B., and Connaughton, V.P.
- ID
- ZDB-PUB-070427-4
- Date
- 2007
- Source
- Zebrafish 4(1): 59-68 (Journal)
- Registered Authors
- Connaughton, Victoria P.
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none Full text @ Zebrafish
Citation
Parker, B., and Connaughton, V.P. (2007) Effects of Nicotine on Growth And Development in Larval Zebrafish. Zebrafish. 4(1):59-68.
Abstract
In this study, larval zebrafish (Danio rerio) were chronically exposed to nicotine concentrations of 5, 10, or 20 mg/L (corresponding to 10, 20, or 40µM) beginning at 1 day postfertilization. Larval growth, morphology, and behavior were examined at day 10. Results indicate that nicotine exposure significantly reduces notochord length and eye diameter (growth), adversely affects the startle responses (behavior), and decreases survival. These findings parallel results on the deleterious effects of nicotine on development in other animals and indicate that zebrafish may be a good model to further study factors affecting vertebrate development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping