PUBLICATION
Divergent Evolution among Teleost V1r Receptor Genes
- Authors
- Pfister, P., Randall, J., Montoya-Burgos, J.I., and Rodriguez, I.
- ID
- ZDB-PUB-070427-24
- Date
- 2007
- Source
- PLoS One 2(1): e379 (Journal)
- Registered Authors
- Keywords
- Zebrafish, Mammalian genomics, Phylogenetic analysis, Olfactory receptor neurons, Sequence alignment, Evolutionary rate, Sequence databases, Pheromone receptors
- MeSH Terms
-
- 5' Untranslated Regions
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution*
- Fishes
- Molecular Sequence Data
- Receptors, Odorant/chemistry
- Receptors, Odorant/genetics*
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid
- Vomeronasal Organ/metabolism*
- PubMed
- 17440615 Full text @ PLoS One
Citation
Pfister, P., Randall, J., Montoya-Burgos, J.I., and Rodriguez, I. (2007) Divergent Evolution among Teleost V1r Receptor Genes. PLoS One. 2(1):e379.
Abstract
The survival of vertebrate species is dependent on the ability of individuals to adequately interact with each other, a function often mediated by the olfactory system. Diverse olfactory receptor repertoires are used by this system to recognize chemicals. Among these receptors, the V1rs, encoded by a very large gene family in most mammals, are able to detect pheromones. Teleosts, which also express V1r receptors, possess a very limited V1r repertoire. Here, taking advantage of the possibility to unequivocally identify V1r orthologs in teleosts, we analyzed the olfactory expression and evolutionary constraints of a pair of clustered fish V1r receptor genes, V1r1 and V1r2. Orthologs of the two genes were found in zebrafish, medaka, and threespine stickleback, but a single representative was observed in tetraodontidae species. Analysis of V1r1 and V1r2 sequences from 12 different euteleost species indicate different evolutionary rates between the two paralogous genes, leading to a highly conserved V1r2 gene and a V1r1 gene under more relaxed selective constraint. Moreover, positively-selected sites were detected in specific branches of the V1r1 clade. Our results suggest a conserved agonist specificity of the V1R2 receptor between euteleost species, its loss in the tetraodontidae lineage, and the acquisition of different chemosensory characteristics for the V1R1 receptor.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping