PUBLICATION
Animal models of human disease: zebrafish swim into view
- Authors
- Lieschke, G.J., and Currie, P.D.
- ID
- ZDB-PUB-070427-23
- Date
- 2007
- Source
- Nature reviews. Genetics 8(5): 353-367 (Review)
- Registered Authors
- Currie, Peter D., Lieschke, Graham J.
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Disease Models, Animal*
- Drug Design
- Drug Evaluation, Preclinical
- Genetic Diseases, Inborn/genetics
- Genetic Diseases, Inborn/pathology
- Humans
- Models, Biological
- Zebrafish*/genetics
- PubMed
- 17440532 Full text @ Nat. Rev. Genet.
Citation
Lieschke, G.J., and Currie, P.D. (2007) Animal models of human disease: zebrafish swim into view. Nature reviews. Genetics. 8(5):353-367.
Abstract
Despite the pre-eminence of the mouse in modelling human disease, several aspects of murine biology limit its routine use in large-scale genetic and therapeutic screening. Many researchers who are interested in an embryologically and genetically tractable disease model have now turned to zebrafish. Zebrafish biology allows ready access to all developmental stages, and the optical clarity of embryos and larvae allow real-time imaging of developing pathologies. Sophisticated mutagenesis and screening strategies on a large scale, and with an economy that is not possible in other vertebrate systems, have generated zebrafish models of a wide variety of human diseases. This Review surveys the achievements and potential of zebrafish for modelling human diseases and for drug discovery and development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping