PUBLICATION

Zebrafish dou yan mutation causes patterning defects and extensive cell death in the retina

Authors
Catalano, A.E., Raymond, P.A., Goldman, D., and Wei, X.
ID
ZDB-PUB-070427-17
Date
2007
Source
Developmental dynamics : an official publication of the American Association of Anatomists   236(5): 1295-1306 (Journal)
Registered Authors
Goldman, Dan, Raymond, Pamela, Wei, Xiangyun
Keywords
retina, dou yan, retinal lamination, cell death, small eye
MeSH Terms
  • Animals
  • Brain/embryology
  • Cell Death
  • Cell Proliferation
  • Eye Abnormalities/embryology
  • Eye Abnormalities/genetics
  • Eye Abnormalities/pathology
  • Female
  • Male
  • Mutation*
  • Organ Size/genetics
  • Phenotype
  • Retina/abnormalities*
  • Retina/embryology
  • Retina/pathology
  • Zebrafish/embryology*
  • Zebrafish/genetics*
PubMed
17436278 Full text @ Dev. Dyn.
Abstract
The size of an organ is largely determined by the number of cells it contains, which in turn is regulated by two opposing processes, cell proliferation and cell death, however, it is generally not clear how cell proliferation and cell death are coordinated during development. Here, we characterize the zebrafish dou yan(mi234) mutation that results in a dramatic reduction of retinal size and a disruption of retinal differentiation and lamination. The retinal size reduction is caused by increased retinal cell death in a non-cell-autonomous manner during early development. The phenotypic defect in dou yan(mi234) arises coincident with the onset of retinal neurogenesis and differentiation. Interestingly, unlike many other small eye mutations, the mutation does not increase the level of cell death in the brain, suggesting that the brain and retina use different mechanisms to maintain cell survival. Identification and further study of the dou yan gene will enhance our understanding of the molecular mechanisms regulating retinal cellular homeostasis, i.e., the balance between cell proliferation and cell death.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping