PUBLICATION

Mycobacterium haemophilum infections of zebrafish (Danio rerio) in research facilities

Authors
Whipps, C.M., Dougan, S.T., and Kent, M.L.
ID
ZDB-PUB-070303-36
Date
2007
Source
FEMS microbiology letters   270(1): 21-26 (Journal)
Registered Authors
Dougan, Scott T., Kent, Michael
Keywords
none
MeSH Terms
  • Animals
  • Animals, Laboratory/microbiology
  • Disease Models, Animal
  • Mycobacterium Infections/microbiology*
  • Mycobacterium Infections/pathology
  • Mycobacterium haemophilum/growth & development*
  • Zebrafish/microbiology*
PubMed
17326751 Full text @ FEMS Microbiol. Lett.
Abstract
In May 2005, a disease outbreak was investigated at a zebrafish (Danio rerio) research facility experiencing severe losses. Mycobacterium haemophilum was isolated from these fish and the disease was subsequently recreated in experimentally infected zebrafish. Fish exhibited signs characteristic of mycobacteriosis, including granuloma formation and severe, diffuse, chronic inflammation. Bacteria were observed in multiple tissues, including the central nervous system. Biofilm samples from the outbreak facility were PCR positive for M. haemophilum, suggesting biofilms might act as a reservoir for infection. Zebrafish appear to be particularly vulnerable to M. haemophilum, and measures such as quarantine and treatment of incoming water should be implemented to minimize the likelihood of introduction of this bacterium to zebrafish research facilities. Zebrafish are already a well-established laboratory animal model for genetics, toxicology and disease, their susceptibility to M. haemophilum may make them useful for the study of this bacterium in the future.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes