PUBLICATION
Small-molecule regulation of zebrafish gene expression
- Authors
- Esengil, H., Chang, V., Mich, J.K., and Chen, J.K.
- ID
- ZDB-PUB-070210-17
- Date
- 2007
- Source
- Nature Chemical Biology 3(3): 154-155 (Journal)
- Registered Authors
- Chen, James K., Esengil, Hanife, Mich, John
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Line
- Embryo, Nonmammalian
- Gene Expression Regulation/physiology*
- Genomics/methods*
- Herpes Simplex Virus Protein Vmw65/biosynthesis
- Herpes Simplex Virus Protein Vmw65/genetics
- Humans
- Insecta
- Receptors, Steroid/genetics
- Receptors, Steroid/physiology
- Trans-Activators/genetics
- Zebrafish/genetics*
- PubMed
- 17237798 Full text @ Nat. Chem. Biol.
Citation
Esengil, H., Chang, V., Mich, J.K., and Chen, J.K. (2007) Small-molecule regulation of zebrafish gene expression. Nature Chemical Biology. 3(3):154-155.
Abstract
The zebrafish has emerged as a versatile model organism for biomedical research, yet its potential has been limited by a lack of conditional reverse-genetic tools. Here we report a chemically inducible gene expression technology that has orthogonality to vertebrate signaling processes, high induction levels, and rapid kinetics. Coupled with tissue-specific promoters, this system provides multidimensional control of gene expression and will enable new models of human disorders and diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping