PUBLICATION
Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures
- Authors
- Aizawa, H., Goto, M., Sato, T., and Okamoto, H.
- ID
- ZDB-PUB-070122-14
- Date
- 2007
- Source
- Developmental Cell 12(1): 87-98 (Journal)
- Registered Authors
- Aizawa, Hidenori, Goto, Midori, Okamoto, Hitoshi, Sato, Tomomi
- Keywords
- none
- MeSH Terms
-
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Gene Expression Regulation, Developmental
- Habenula/anatomy & histology
- Habenula/cytology*
- Habenula/embryology*
- Animals
- Models, Neurological
- Neurons/cytology*
- Time Factors
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/metabolism
- Cation Transport Proteins
- Receptors, Notch/metabolism
- RNA, Messenger/genetics
- RNA, Messenger/metabolism
- Body Patterning/physiology*
- Signal Transduction
- Embryo, Nonmammalian/anatomy & histology
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/embryology
- Zebrafish/anatomy & histology*
- Zebrafish/embryology*
- Cell Differentiation*
- Receptor Protein-Tyrosine Kinases/genetics
- Receptor Protein-Tyrosine Kinases/metabolism
- PubMed
- 17199043 Full text @ Dev. Cell
Citation
Aizawa, H., Goto, M., Sato, T., and Okamoto, H. (2007) Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures. Developmental Cell. 12(1):87-98.
Abstract
The habenular neurons on both sides of the zebrafish diencephalon show an asymmetric (laterotopic) axonal projection pattern into the interpeduncular nucleus. We previously revealed that the habenula could be subdivided into medial and lateral subnuclei, and a prominent left-right difference in the size ratio of these subnuclei accounts for the asymmetry in its neural connectivity. In the present study, birth date analysis showed that neural precursors for the lateral subnuclei were born at earlier stages than those for the medial subnuclei. More neurons for the early-born lateral subnuclei were generated on the left side, while more neurons for the late-born medial subnuclei were generated on the right side. Genetic hyperactivation and repression of Notch signaling revealed that differential timing determines both specificity and asymmetry in the neurogenesis of neural precursors for the habenular subnuclei.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping