PUBLICATION
PCR survey of hox genes in the goldfish Carassius auratus auratus
- Authors
- Luo, J., Stadler, P.F., He, S., and Meyer, A.
- ID
- ZDB-PUB-061229-6
- Date
- 2007
- Source
- Journal of experimental zoology. Part B, Molecular and developmental evolution 308(3): 250-258 (Journal)
- Registered Authors
- Meyer, Axel
- Keywords
- none
- MeSH Terms
-
- Animals
- Base Sequence
- DNA Primers
- Genes, Homeobox/genetics*
- Goldfish/genetics*
- INDEL Mutation/genetics
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polyploidy*
- Pseudogenes/genetics
- Sequence Analysis, DNA
- Species Specificity
- PubMed
- 17171698 Full text @ J. Exp. Zool. B Mol. Dev. Evol.
Citation
Luo, J., Stadler, P.F., He, S., and Meyer, A. (2007) PCR survey of hox genes in the goldfish Carassius auratus auratus. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(3):250-258.
Abstract
A tetraploidization event took place in the cyprinid lineage leading to goldfishes about 15 million years ago. A PCR survey for Hox genes in the goldfish Carassius auratus auratus (Actinopterygii: Cyprinidae) was performed to assess the consequences of this genome duplication. Not surprisingly, the genomic organization of the Hox gene clusters of goldfish is similar to that of the closely related zebrafish (Danio rerio). However, the goldfish exhibits a much larger number of recent pseudogenes, which are characterized by indels. These findings are consistent with the hypothesis that dosage effects cause selection pressure to rapidly silence crucial developmental regulators after a tetraploidization event.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping