ZFIN ID: ZDB-PUB-061229-14
Getting to the heart of regeneration in zebrafish
Poss, K.D.
Date: 2007
Source: Seminars in cell & developmental biology   18(1): 36-45 (Review)
Registered Authors: Poss, Kenneth D.
Keywords: Cardiac muscle, Zebrafish, Progenitor cells, Epicardium, Neovascularization, Regeneration
MeSH Terms:
  • Amphibians/physiology
  • Animals
  • Heart/physiology*
  • Humans
  • Mammals/physiology
  • Models, Biological
  • Regeneration*/genetics
  • Zebrafish/genetics
  • Zebrafish/physiology*
PubMed: 17178459 Full text @ Sem. Cell Dev. Biol.
A scientific and clinical prerogative of the 21st century is to stimulate the regenerative ability of the human heart. While the mammalian heart shows little or no natural regeneration in response to injury, certain non-mammalian vertebrates possess an elevated capacity for cardiac regeneration. Adult zebrafish restore ventricular muscle removed by surgical resection, events that involve little or no scarring. Recent studies have begun to reveal cellular and molecular mechanisms of this regenerative process that have exciting implications for human cardiac biology and disease.