PUBLICATION
Getting to the heart of regeneration in zebrafish
- Authors
- Poss, K.D.
- ID
- ZDB-PUB-061229-14
- Date
- 2007
- Source
- Seminars in cell & developmental biology 18(1): 36-45 (Review)
- Registered Authors
- Poss, Kenneth D.
- Keywords
- Cardiac muscle, Zebrafish, Progenitor cells, Epicardium, Neovascularization, Regeneration
- MeSH Terms
-
- Amphibians/physiology
- Animals
- Heart/physiology*
- Humans
- Mammals/physiology
- Models, Biological
- Regeneration*/genetics
- Zebrafish/genetics
- Zebrafish/physiology*
- PubMed
- 17178459 Full text @ Sem. Cell Dev. Biol.
Citation
Poss, K.D. (2007) Getting to the heart of regeneration in zebrafish. Seminars in cell & developmental biology. 18(1):36-45.
Abstract
A scientific and clinical prerogative of the 21st century is to stimulate the regenerative ability of the human heart. While the mammalian heart shows little or no natural regeneration in response to injury, certain non-mammalian vertebrates possess an elevated capacity for cardiac regeneration. Adult zebrafish restore ventricular muscle removed by surgical resection, events that involve little or no scarring. Recent studies have begun to reveal cellular and molecular mechanisms of this regenerative process that have exciting implications for human cardiac biology and disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping