PUBLICATION
Conditional Transgene and Gene Targeting Methodologies in Zebrafish
- Authors
- Deiters, A., and Yoder, J.A.
- ID
- ZDB-PUB-061226-1
- Date
- 2006
- Source
- Zebrafish 3(4): 415-429 (Review)
- Registered Authors
- Yoder, Jeffrey A.
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none
Citation
Deiters, A., and Yoder, J.A. (2006) Conditional Transgene and Gene Targeting Methodologies in Zebrafish. Zebrafish. 3(4):415-429.
Abstract
The zebrafish has become a powerful tool for dissecting vertebrate gene function during embryogenesis. Numerous molecular systems have been developed to examine gene function in zebrafish, including transgenics for creating lineage-tracer lines of zebrafish that express a fluorescent protein as a marker for specific populations of cells, and antisense strategies, primarily morpholinos, for knocking down gene function. The focus of this review is to summarize the pros and cons of the currently available systems for functional genomics in zebrafish, and to discuss the need for future methodologies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping