|ZFIN ID: ZDB-PUB-061205-16|
A two-step mechanism underlies the planar polarization of regenerating sensory hair cells
Lopez-Schier, H., and Hudspeth, A.J.
|Source:||Proceedings of the National Academy of Sciences of the United States of America 103(49): 18615-18620 (Journal)|
|Registered Authors:||Hudspeth, A.J. (Jim), Lopez-Schier, Hernan|
|Keywords:||auditory system, balance, hearing, lateral line, vestibular system|
|PubMed:||17124170 Full text @ Proc. Natl. Acad. Sci. USA|
Lopez-Schier, H., and Hudspeth, A.J. (2006) A two-step mechanism underlies the planar polarization of regenerating sensory hair cells. Proceedings of the National Academy of Sciences of the United States of America. 103(49):18615-18620.
ABSTRACTThe restoration of planar cell polarity is an essential but poorly understood step toward physiological recovery during sensory-organ regeneration. Investigating this issue in the lateral line of the zebrafish, we found that hair cells regenerate in pairs along a single axis established by the restricted localization and oriented division of their progenitors. By analyzing mutants lacking the planar-polarity determinant Vangl2, we ascertained that the uniaxial production of hair cells and the subsequent orientation of their hair bundles are controlled by distinct pathways, whose combination underlies the establishment of hair-cell orientation during development and regeneration. This mechanism may represent a general principle governing the long-term maintenance of planar cell polarity in remodeling epithelia.