PUBLICATION
Different words, same meaning: understanding the languages of the genome
- Authors
- Elgar, G.
- ID
- ZDB-PUB-061020-5
- Date
- 2006
- Source
- Trends in genetics : TIG 22(12): 639-641 (Review)
- Registered Authors
- Elgar, Greg
- Keywords
- none
- MeSH Terms
-
- Animals
- Conserved Sequence
- Evolution, Molecular
- Gene Expression Regulation, Developmental*
- Genome*
- Genome, Human
- Humans
- Proto-Oncogene Proteins c-ret/genetics*
- Proto-Oncogene Proteins c-ret/physiology*
- Regulatory Elements, Transcriptional
- Regulatory Sequences, Nucleic Acid
- Species Specificity
- Tetraodontiformes
- Zebrafish
- PubMed
- 17010471 Full text @ Trends Genet.
Citation
Elgar, G. (2006) Different words, same meaning: understanding the languages of the genome. Trends in genetics : TIG. 22(12):639-641.
Abstract
There is undeniable value in using sequence comparison to identify putative regulatory sequences. However, a recent report has demonstrated that not all regulatory sequences are evolutionarily conserved. Cis-acting sequences around the RET gene, conserved in mammals but not in fish, are able to reproduce patterns of RET expression in zebrafish embryos. It is as yet unclear whether these sequences are 'below the radar' of current sequence alignment tools or whether their functional homology is not sequence based.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping