PUBLICATION

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

Authors
Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L.G., Bakkers, J., Mayo, K.H.,Poirier, F., and Griffioen, A.W.
ID
ZDB-PUB-061020-46
Date
2006
Source
Proceedings of the National Academy of Sciences of the United States of America   103(43): 15975-15980 (Journal)
Registered Authors
Bakkers, Jeroen, Postel, Ruben
Keywords
none
MeSH Terms
  • Disease Progression
  • Animals
  • Humans
  • Neoplasms/blood supply*
  • Neoplasms/genetics
  • Neoplasms/metabolism*
  • Neoplasms/therapy
  • Endothelial Cells/metabolism
  • Endothelial Cells/pathology
  • Neoplasm Transplantation
  • Gene Expression Regulation, Neoplastic
  • Cell Proliferation
  • Cell Movement
  • Mice, Knockout
  • Mice
  • Protein Binding
  • Galectin 1/deficiency
  • Galectin 1/genetics
  • Galectin 1/metabolism*
  • Cells, Cultured
  • Proteins/metabolism
  • Zebrafish
(all 22)
PubMed
17043243 Full text @ Proc. Natl. Acad. Sci. USA
Abstract
We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.
Genes / Markers
Figures
Figure Gallery (1 images)
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Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
y1TgTransgenic Insertion
    1 - 1 of 1
    Show
    Human Disease / Model
    No data available
    Sequence Targeting Reagents
    Target Reagent Reagent Type
    lgals2aMO1-lgals2aMRPHLNO
    lgals2aMO2-lgals2aMRPHLNO
    lgals2bMO2-lgals2bMRPHLNO
    lgals2bMO1-lgals2bMRPHLNO
    1 - 4 of 4
    Show
    Fish
    Fish
    WT
    y1Tg
    1 - 2 of 2
    Show
    Antibodies
    No data available
    Orthology
    No data available
    Engineered Foreign Genes
    No data available
    Mapping
    No data available
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    Citation
    Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L.G., Bakkers, J., Mayo, K.H.,Poirier, F., and Griffioen, A.W. (2006) Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proceedings of the National Academy of Sciences of the United States of America. 103(43):15975-15980.