PUBLICATION
Splitting pairs: the diverging fates of duplicated genes
- Authors
- Prince, V.E., and Pickett, F.B.
- ID
- ZDB-PUB-060926-1
- Date
- 2002
- Source
- Nature reviews. Genetics 3(11): 827-837 (Review)
- Registered Authors
- Pickett, F. Bryan, Prince, Victoria E.
- Keywords
- none
- MeSH Terms
-
- Animals
- Evolution, Molecular*
- Forecasting
- Gene Duplication*
- Genes, Homeobox
- Genomics/trends
- Humans
- Plants/genetics
- Vertebrates/genetics
- PubMed
- 12415313 Full text @ Nat. Rev. Genet.
Citation
Prince, V.E., and Pickett, F.B. (2002) Splitting pairs: the diverging fates of duplicated genes. Nature reviews. Genetics. 3(11):827-837.
Abstract
Many genes are members of large families that have arisen during evolution through gene duplication events. Our increasing understanding of gene organization at the scale of whole genomes is revealing further evidence for the extensive retention of genes that arise during duplication events of various types. Duplication is thought to be an important means of providing a substrate on which evolution can work. An understanding of gene duplication and its resolution is crucial for revealing mechanisms of genetic redundancy. Here, we consider both the theoretical framework and the experimental evidence to explain the preservation of duplicated genes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping