PUBLICATION
Genetic and developmental basis of cichlid trophic diversity
- Authors
- Albertson, R.C., and Kocher, T.D.
- ID
- ZDB-PUB-060724-1
- Date
- 2006
- Source
- Heredity 97(3): 211-221 (Review)
- Registered Authors
- Albertson, R. Craig, Kocher, Thomas D.
- Keywords
- cichlid, adaptive radiation, jaw, bmp4, genetic architecture, cranial neural crest
- MeSH Terms
-
- Animals
- Biological Evolution
- Cichlids/anatomy & histology*
- Cichlids/genetics
- Cichlids/growth & development*
- Feeding Behavior*
- Gene Expression Regulation, Developmental
- Jaw/anatomy & histology*
- Maxillofacial Development/genetics*
- PubMed
- 16835594 Full text @ Heredity
Citation
Albertson, R.C., and Kocher, T.D. (2006) Genetic and developmental basis of cichlid trophic diversity. Heredity. 97(3):211-221.
Abstract
Cichlids have undergone extensive evolutionary modifications of their feeding apparatus, making them an ideal model to study the factors that underlie craniofacial diversity. Recent studies have provided critical insights into the molecular mechanisms that have contributed to the origin and maintenance of cichlid trophic diversity. We review this body of work, which shows that the cichlid jaw is regulated by a few genes of major additive effect, and is composed of modules that have evolved under strong divergent selection. Adaptive variation in cichlid jaw shape is evident early in development and is associated with allelic variation in and expression of bmp4. Modulating this growth factor in the experimentally tractable zebrafish model reproduces natural variation in cichlid jaw shape, supporting a role for bmp4 in craniofacial evolution. These data demonstrate the utility of the cichlid jaw as a model for studying the genetic and developmental basis of evolutionary changes in craniofacial morphology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping