ZFIN ID: ZDB-PUB-060703-16
The zebrafish as a model system for assessing the reinforcing properties of drugs of abuse
Ninkovic, J., and Bally-Cuif, L.
Date: 2006
Source: Methods (San Diego, Calif.)   39(3): 262-274 (Journal)
Registered Authors: Bally-Cuif, Laure, Ninkovic, Jovica
Keywords: Zebrafish, Addiction, Conditioned place preference (CPP), Aversion, Learning and memory, d-Amphetamine, Behavior
MeSH Terms:
  • Animals
  • Behavior, Addictive/genetics
  • Conditioning, Psychological
  • Dextroamphetamine/toxicity
  • Disease Models, Animal*
  • Illicit Drugs/toxicity
  • Mutation
  • Reinforcement, Psychology*
  • Substance-Related Disorders/genetics*
  • Toxicity Tests/instrumentation
  • Toxicity Tests/methods
  • Zebrafish/genetics*
  • Zebrafish/physiology
PubMed: 16809048 Full text @ Methods
Recent reports make use of the zebrafish to study complex behavior such as addiction, anxiety, or learning and memory. We have established reliable tests and appropriate controls to measure these behavioral parameters in the zebrafish adult. Our assays are robust enough to permit the detection of dominant mutations affecting drug-induced reward, and therefore can be used in forward genetic screens. We provide the reader with the technical details of these tests, as well as their appropriate and crucial, although often overlooked, control assays. In particular, our results make it possible to use the zebrafish as a promising model to identify new genetic components of the reward pathway, or other measurable behaviors.