PUBLICATION

Analysis of origin and growth of the thyroid gland in zebrafish

Authors
Alt, B., Reibe, S., Feitosa, N.M., Elsalini, O.A., Wendl, T., and Rohr, K.B.
ID
ZDB-PUB-060517-11
Date
2006
Source
Developmental Dynamics : an official publication of the American Association of Anatomists   235(7): 1872-1883 (Journal)
Registered Authors
Alt, Burkhard, Elsalini, Osama, Feitosa, Natalia Martins, Reibe, Saskia, Rohr, Klaus, Wendl, Thomas
Keywords
thyroglobulin, sodium/iodide symporter, calcitonin, cathepsin b, fate map, tsh, TARAM-A, goitrogen, endoderm
MeSH Terms
  • Calcitonin/metabolism
  • Zebrafish/embryology*
  • Zebrafish/growth & development*
  • Cell Lineage/physiology
  • Cell Differentiation
  • Zebrafish Proteins/biosynthesis
  • Endoderm/cytology
  • Endoderm/metabolism
  • Thyroid Gland/embryology
  • Thyroid Gland/growth & development*
  • Thyroid Gland/metabolism
  • Embryo, Nonmammalian/embryology
  • Morphogenesis
  • Animals
  • Larva/growth & development
  • Larva/metabolism
(all 16)
PubMed
16680726 Full text @ Dev. Dyn.
Abstract
The zebrafish thyroid gland shows a unique pattern of growth as a differentiated endocrine gland. Here, we analyze the onset of differentiation, the contribution of lineages, and the mode of growth of this gland. The expression of genes involved in hormone production and the establishment of epithelial polarity show that differentiation into a first thyroid follicle takes place early during embryonic development. Thyroid follicular tissue then grows along the pharyngeal midline, initially independently of thyroid stimulating hormone. Lineage analysis reveals that thyroid follicle cells are exclusively recruited from the pharyngeal endoderm. The ultimobranchial bodies that merge with the thyroid in mammals form separate glands in zebrafish as visualized by calcitonin precursor gene expression. Mosaic analysis suggests that the first thyroid follicle differentiating at 55 hours postfertilization corresponds later to the most anterior follicle and that new follicles are added caudally.
Genes / Markers
Figures
Figure Gallery (5 images)
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Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
t24149
    		Point Mutation
    tu29a
      		Point Mutation
      1 - 2 of 2
      Show
      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      No data available
      Fish
      Fish
      fgf3t24149/t24149 (TU)
      pax2atu29a/tu29a
      WT
      1 - 3 of 3
      Show
      Antibodies
      No data available
      Orthology
      No data available
      Engineered Foreign Genes
      No data available
      Mapping
      No data available
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      Citation
      Alt, B., Reibe, S., Feitosa, N.M., Elsalini, O.A., Wendl, T., and Rohr, K.B. (2006) Analysis of origin and growth of the thyroid gland in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(7):1872-1883.