PUBLICATION

Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish

Authors
Panagos, P.G., Dobrinski, K.P., Chen, X., Grant, A.W., Traver, D., Djeu, J.Y., Wei, S., and Yoder, J.A.
ID
ZDB-PUB-060213-3
Date
2006
Source
Immunogenetics   58(1): 31-40 (Journal)
Registered Authors
Dobrinski, Kim P., Grant, Amanda W., Traver, David, Yoder, Jeffrey A.
Keywords
C-type lectin, ITIM, Natural killer cells, Signaling motifs
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Cell Survival/physiology
  • Chromosomes*
  • Chromosomes, Artificial, Bacterial
  • Killer Cells, Natural/metabolism
  • Lectins, C-Type/chemistry
  • Lectins, C-Type/genetics*
  • Lectins, C-Type/metabolism
  • Lectins, C-Type/physiology
  • Lymphocytes/metabolism*
  • Models, Molecular
  • Molecular Sequence Data
  • Myeloid Cells/metabolism*
  • Phylogeny
  • Zebrafish/genetics*
  • Zebrafish/immunology
  • Zebrafish/metabolism
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism*
PubMed
16467987 Full text @ Immunogenetics
Abstract
The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping