ZFIN ID: ZDB-PUB-060210-23
Comparative genomics provides evidence for close evolutionary relationships between the urotensin II and somatostatin gene families
Tostivint, H., Joly, L., Lihrmann, I., Parmentier, C., Lebon, A., Morisson, M., Calas, A., Ekker, M., and Vaudry, H.
Date: 2006
Source: Proceedings of the National Academy of Sciences of the United States of America   103(7): 2237-2247 (Journal)
Registered Authors: Ekker, Marc, Joly, Lucille, Tostivint, Hervé
Keywords: duplication, multigenic family, neuropeptides, radiation hybrid mapping
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Chickens
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1/genetics
  • Chromosomes, Human, Pair 3/genetics
  • Evolution, Molecular*
  • Gene Duplication
  • Genes/genetics
  • Genomics
  • Humans
  • Mice
  • Molecular Sequence Data
  • Peptides/chemistry
  • Peptides/genetics
  • Phylogeny
  • Rats
  • Somatostatin/chemistry
  • Somatostatin/classification*
  • Somatostatin/genetics*
  • Urotensins/chemistry
  • Urotensins/classification*
  • Urotensins/genetics*
  • Zebrafish
PubMed: 16467151 Full text @ Proc. Natl. Acad. Sci. USA
Although urotensin II (UII) and somatostatin 1 (SS1) exhibit some structural similarities, their precursors do not show any appreciable sequence identity and, thus, it is widely accepted that the UII and SS1 genes do not derive from a common ancestral gene. The recent characterization of novel isoforms of these two peptides, namely urotensin II-related peptide (URP) and somatostatin 2 (SS2)/cortistatin (CST), provides new opportunity to revisit the phylogenetic relationships of UII and SS1 using a comparative genomics approach. In the present study, by radiation hybrid mapping and in silico sequence analysis, we have determined the chromosomal localization of the genes encoding UII- and somatostatin-related peptides in several vertebrate species, including human, chicken, and zebrafish. In most of the species investigated, the UII and URP genes are closely linked to the SS2/CST and SS1 genes, respectively. We also found that the UII-SS2/CST locus and the URP/SS1 locus are paralogous. Taken together, these data indicate that the UII and URP genes, on the one hand, and the SS1 and SS2/CST genes, on the other hand, arose through a segmental duplication of two ancestral genes that were already physically linked to each other. Our results also suggest that these two genes arose themselves through a tandem duplication of a single ancestral gene. It thus appears that the genes encoding UII- and somatostatin-related peptides belong to the same superfamily.