PUBLICATION
Evolution of myelin proteolipid proteins: Gene duplication in teleosts and expression pattern divergence
- Authors
- Schweitzer, J., Becker, T., Schachner, M., Nave, K.A., and Werner, H.
- ID
- ZDB-PUB-051121-5
- Date
- 2006
- Source
- Molecular and cellular neurosciences 31(1): 161-177 (Journal)
- Registered Authors
- Becker, Thomas, Schachner, Melitta, Schweitzer, Jörn
- Keywords
- Myelin protein evolution, Pelizaeus–Merzbacher disease, PLP/DM20, Gpm6a, Gpm6b, Tetraspan transmembrane proteins, Alternative splicing, Teleostei, Genome duplication, Nerve regeneration, Ascidian Ciona intestinalis, Drosophila melanogaster, Apis mellifera, Anopheles gambiae, Danio rerio, CNS regeneration, Remyelination, Neurite outgrowth, Optic nerve lesion
- MeSH Terms
-
- Sequence Alignment
- Animals
- Amino Acid Sequence
- Genetic Variation*
- Genome
- Gene Expression Regulation*
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Protein Conformation
- Fishes/genetics*
- Consensus Sequence
- Zebrafish Proteins/chemistry
- Zebrafish Proteins/genetics
- Humans
- Models, Molecular
- Gene Duplication
- Zebrafish
- Myelin Proteolipid Protein/chemistry
- Myelin Proteolipid Protein/genetics*
- Evolution, Molecular*
- PubMed
- 16289898 Full text @ Mol. Cell Neurosci.
Citation
Schweitzer, J., Becker, T., Schachner, M., Nave, K.A., and Werner, H. (2006) Evolution of myelin proteolipid proteins: Gene duplication in teleosts and expression pattern divergence. Molecular and cellular neurosciences. 31(1):161-177.
Abstract
The coevolution of neurons and their supporting glia to the highly specialized axon-myelin unit included the recruitment of proteolipids as neuronal glycoproteins (DMbeta, DMgamma) or myelin proteins (DMalpha/PLP/DM20). Consistent with a genome duplication at the root of teleosts, we identified three proteolipid pairs in zebrafish, termed DMalpha1 and DMalpha2, DMbeta1 and DMbeta2, DMgamma1 and DMgamma2. The paralogous amino acid sequences diverged remarkably after gene duplication, indicating functional specialization. Each proteolipid has adopted a distinct spatio-temporal expression pattern in neural progenitors, neurons, and in glia. DMalpha2, the closest homolog to mammalian PLP/DM20, is coexpressed with P0 in oligodendrocytes and upregulated after optic nerve lesion. DMgamma2 is expressed in multipotential stem cells, and the other four proteolipids are confined to subsets of CNS neurons. Comparing protein sequences and gene structures from birds, teleosts, one urochordate species, and four invertebrates, we have reconstructed major steps in the evolution of proteolipids.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping