|ZFIN ID: ZDB-PUB-050907-3|
Assembly of trigeminal sensory Ganglia by chemokine signaling
Knaut, H., Blader, P., Strähle, U., and Schier, A.F.
|Source:||Neuron 47(5): 653-666 (Journal)|
|Registered Authors:||Blader, Patrick, Knaut, Holger, Schier, Alexander, Strähle, Uwe|
|PubMed:||16129396 Full text @ Neuron|
Knaut, H., Blader, P., Strähle, U., and Schier, A.F. (2005) Assembly of trigeminal sensory Ganglia by chemokine signaling. Neuron. 47(5):653-666.
ABSTRACTSensory neurons with related functions form ganglia, but how these precisely positioned clusters are assembled has been unclear. Here, we use the zebrafish trigeminal sensory ganglion as a model to address this question. We find that some trigeminal sensory neurons are born at the position where the ganglion is assembled, whereas others are born at a distance and have to migrate against opposing morphogenetic movements to reach the site of ganglion assembly. Loss of Cxcr4b-mediated chemokine signaling results in the formation of mispositioned ganglia. Conversely, ectopic sources of the chemokine SDF1a can attract sensory neurons. Transplantation experiments reveal that neuron-neuron interaction and the adhesion molecules E- and N-Cadherin also contribute to ganglion assembly. These results indicate that ganglion formation depends on the interplay of birthplace, chemokine attraction, cell-cell interaction, and cadherin-mediated adhesion.