ZFIN ID: ZDB-PUB-050607-3
Hedgehog signalling and the specification of muscle cell identity in the Zebrafish embryo
Ingham, P.W., and Kim, H.R.
Date: 2005
Source: Experimental cell research   306(2): 336-342 (Review)
Registered Authors: Ingham, Philip, Kim, Rosemary
Keywords: Hedgehog signalling; Zebrafish; Muscle cell; Blimp1; Slow twitch fibre
MeSH Terms:
  • Animals
  • Cell Differentiation
  • DNA-Binding Proteins
  • Embryo, Nonmammalian/metabolism*
  • Embryonic Induction
  • Gene Expression Regulation, Developmental/physiology*
  • Hedgehog Proteins
  • Muscle, Skeletal/embryology*
  • Nuclear Proteins
  • Repressor Proteins/metabolism
  • Signal Transduction/physiology*
  • Trans-Activators/physiology*
  • Transcription Factors/metabolism
  • Zebrafish/embryology*
  • Zebrafish Proteins
PubMed: 15925589 Full text @ Exp. Cell Res.
Signalling by members of the Hedgehog family of secreted proteins plays a central role in the development of many animal species. In the zebrafish embryo, the specification of myoblast fates is controlled by Hedgehog signals emanating from axial midline structures. Distinct muscle cell identities are induced by varying levels of signalling activity. The SET domain transcription factor, Blimp1, is a key target of Hedgehog signalling in this process.