PUBLICATION
Identification and characterisation of two runx2 homologues in zebrafish with different expression patterns
- Authors
- van der Meulen, T., Kranenbarg, S., Schipper, H., Samallo, J., van Leeuwen, J.L., and Franssen, H.
- ID
- ZDB-PUB-050518-15
- Date
- 2005
- Source
- BBA Gene Structure and Expression 1729(2): 105-117 (Journal)
- Registered Authors
- Samallo, John, Schipper, Henk, van der Meulen, Talitha, van Leeuwen, Johan
- Keywords
- Zebrafish; Runx2; Gene duplication; Differential expression; Splice form; Gene divergence
- MeSH Terms
-
- 5' Untranslated Regions/genetics
- Amino Acid Sequence
- Animals
- Bone Regeneration
- Female
- Gene Expression Regulation, Developmental
- Genetic Variation
- Male
- Molecular Sequence Data
- Protein Isoforms/biosynthesis
- Protein Isoforms/genetics
- Transcription Factors/biosynthesis
- Transcription Factors/genetics*
- Zebrafish/genetics*
- Zebrafish Proteins/biosynthesis
- Zebrafish Proteins/genetics*
- PubMed
- 15894389 Full text @ BBA Gene Structure and Expression
Citation
van der Meulen, T., Kranenbarg, S., Schipper, H., Samallo, J., van Leeuwen, J.L., and Franssen, H. (2005) Identification and characterisation of two runx2 homologues in zebrafish with different expression patterns. BBA Gene Structure and Expression. 1729(2):105-117.
Abstract
Genome and gene duplications are considered to be the impetus to generate new genes, as the presence of multiple copies of a gene allows for paralogues to adopt novel function. After at least two rounds of genome/gene duplication, the Runt gene family consists of three members in vertebrates, instead of one in invertebrates. One of the family members, Runx2, plays a key role in the development of bone, a tissue that first occurs in vertebrates. The family has thus gained new gene function in the course of evolution. Two Runx2 genes were cloned in the vertebrate model system the zebrafish (Danio rerio). The expression patterns of the two genes differ and their kinetics differ up to four fold. In addition, splice forms exist that are novel when compared with mammals. Together, these findings comprise opportunities for selection and retention of the paralogues towards divergent and possibly new function.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping