PUBLICATION
fsi Zebrafish Show Concordant Reversal of Laterality of Viscera, Neuroanatomy, and a Subset of Behavioral Responses
- Authors
- Barth, K.A., Miklosi, A., Watkins, J., Bianco, I.H., Wilson, S.W., and Andrew, R.J.
- ID
- ZDB-PUB-050513-12
- Date
- 2005
- Source
- Current biology : CB 15(9): 844-850 (Journal)
- Registered Authors
- Andrew, Richard J., Barth, Anukampa, Bianco, Isaac, Wilson, Steve
- Keywords
- none
- MeSH Terms
-
- Analysis of Variance
- Animals
- Behavior, Animal/physiology*
- Body Patterning/physiology*
- Central Nervous System/embryology*
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/physiology*
- Functional Laterality/physiology*
- Green Fluorescent Proteins
- Habenula/cytology
- Immunohistochemistry
- In Situ Hybridization
- Mutation/genetics
- Psychomotor Performance/physiology
- Transgenes/genetics
- Video Recording
- Viscera/embryology*
- Zebrafish/embryology*
- PubMed
- 15886103 Full text @ Curr. Biol.
Citation
Barth, K.A., Miklosi, A., Watkins, J., Bianco, I.H., Wilson, S.W., and Andrew, R.J. (2005) fsi Zebrafish Show Concordant Reversal of Laterality of Viscera, Neuroanatomy, and a Subset of Behavioral Responses. Current biology : CB. 15(9):844-850.
Abstract
Asymmetries in CNS neuroanatomy are assumed to underlie the widespread cognitive and behavioral asymmetries in vertebrates. Studies in humans have shown that the laterality of some cognitive asymmetries is independent of the laterality of the viscera; discrete mechanisms may therefore regulate visceral and neural lateralization. However, through analysis of visceral, neuroanatomical, and behavioral asymmetries in the frequent-situs-inversus (fsi) line of zebrafish, we show that the principal left-right body asymmetries are coupled to certain brain asymmetries and lateralized behaviors. fsi fish with asymmetry defects show concordant reversal of heart, gut, and neuroanatomical asymmetries in the diencephalon. Moreover, the neuroanatomical reversals in reversed fsi fish correlate with reversal of some behavioral responses in both fry and adult fsi fish. Surprisingly, two behavioral asymmetries do not reverse, suggesting that at least two separable mechanisms must influence functional lateralization in the CNS. Partial reversal of CNS asymmetries may generate new behavioral phenotypes; supporting this idea, reversed fsi fry differ markedly from their normally lateralized siblings in their behavioral response to a novel visual feature. Revealing a link between visceral and brain asymmetry and lateralized behavior, our studies help to explain the complexity of the relationship between the lateralities of visceral and neural asymmetries.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping