PUBLICATION
Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons
- Authors
- Sapede, D., Rossel, M., Dambly-Chaudiere, C., and Ghysen, A.
- ID
- ZDB-PUB-050125-6
- Date
- 2005
- Source
- Proceedings of the National Academy of Sciences of the United States of America 102(5): 1714-1718 (Journal)
- Registered Authors
- Ghysen, Alain, Sapede, Dora
- Keywords
- cell migration, hindbrain, octavolateral efferents, axon guidance
- MeSH Terms
-
- Afferent Pathways/embryology
- Afferent Pathways/physiology*
- Animals
- Cell Movement
- Chemokine CXCL12
- Chemokines, CXC/physiology*
- Embryo, Nonmammalian/physiology
- Facial Nerve/embryology
- Facial Nerve/physiology*
- Motor Neurons/physiology*
- Zebrafish/embryology
- Zebrafish Proteins/physiology
- PubMed
- 15659553 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Sapede, D., Rossel, M., Dambly-Chaudiere, C., and Ghysen, A. (2005) Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons. Proceedings of the National Academy of Sciences of the United States of America. 102(5):1714-1718.
Abstract
Most sensory systems are innervated by efferent neurons as well as by afferent neurons. The efferent innervation modulates the sensitivity of the receptor cells or of the sensory terminals. In the posterior lateral line system of the zebrafish, two efferent nuclei have been described in the hindbrain. Here we examine the development of the efferent neurons. We show that their axons are guided toward the target organ along the lateral line nerve while their cell bodies migrate posteriorward across rhombomeres to achieve their final position in rhombomeres 6/7. This migration depends on the SDF1 chemokine. We show that the migration of motor neurons of the facial nucleus from rhombomere 4 to 6 is also affected in sdf1a morphants (embryos injected with morpholine-conjugated antisense oligonucleotides). We propose that SDF1/CXCR4-mediated cell migration is preferentially associated with movement along the anteroposterior axis of the animal.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping