PUBLICATION
cfm is a novel gene uniquely expressed in developing forebrain and midbrain, but its null mutant exhibits no obvious phenotype
- Authors
- Hirano, M., Murata, T., Furushima, K., Kiyonari, H., Nakamura, M., Suda, Y., and Aizawa, S.
- ID
- ZDB-PUB-050125-13
- Date
- 2005
- Source
- Gene expression patterns : GEP 5(3): 439-444 (Journal)
- Registered Authors
- Keywords
- Forebrain; Midbrain; Diencephalon; MAP kinase; cfm; cfm2; Mouse; Mutant
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Chickens
- Humans
- In Situ Hybridization
- Mesencephalon/embryology*
- Mesencephalon/metabolism
- Mice
- Microfilament Proteins
- Molecular Sequence Data
- Mutation
- Nerve Tissue Proteins/chemistry
- Nerve Tissue Proteins/genetics*
- Nerve Tissue Proteins/physiology*
- Phenotype
- Prosencephalon/embryology*
- Prosencephalon/metabolism
- Sequence Homology, Amino Acid
- Zebrafish
- PubMed
- 15661651 Full text @ Gene Expr. Patterns
Citation
Hirano, M., Murata, T., Furushima, K., Kiyonari, H., Nakamura, M., Suda, Y., and Aizawa, S. (2005) cfm is a novel gene uniquely expressed in developing forebrain and midbrain, but its null mutant exhibits no obvious phenotype. Gene expression patterns : GEP. 5(3):439-444.
Abstract
A novel gene, cfm, that is expressed uniquely during early forebrain and midbrain development was isolated, and its null mutant was generated. cfm does not have any known functional domains, but is conserved in human, chick, Xenopus and zebrafish; a site of phosphorylation by MAP kinase exists in one of the domains conserved among them. Its expression was initially found at the 5-somite stage in the future midbrain and caudal forebrain region. The expression in mesencephalon subsequently decreased, was found in a stripe in the mid mesencephalon at E9.0. The expression in diencephalon was restricted to the dorsal thalamic region by E9.5 and to epiphysis at E12.5. In mouse a cognate, cfm2, exists that is expressed uniquely in the somite just formed and the presomite to be segmented, but not in forebrain or midbrain during early development. However, the cfm null mutant was live-born without any apparent defects.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping