PUBLICATION
Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor
- Authors
- Trueb, B., Neuhauss, S.C., Baertschi, S., Rieckmann, T., Schild, C., and Taeschler, S.
- ID
- ZDB-PUB-050120-5
- Date
- 2005
- Source
- BBA Gene Structure and Expression 1727(1): 65-74 (Journal)
- Registered Authors
- Neuhauss, Stephan
- Keywords
- Danio rerio; Fibroblast growth factor receptor, FGFR; Fugu rubripes; Whole-genome duplication; Zebrafish
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Evolution, Molecular
- Fishes/genetics
- Molecular Sequence Data
- Phylogeny
- Receptor Protein-Tyrosine Kinases/chemistry
- Receptor Protein-Tyrosine Kinases/genetics*
- Receptor, Fibroblast Growth Factor, Type 1
- Receptor, Fibroblast Growth Factor, Type 5
- Receptors, Fibroblast Growth Factor/chemistry
- Receptors, Fibroblast Growth Factor/genetics*
- Zebrafish/genetics
- PubMed
- 15652159 Full text @ BBA Gene Structure and Expression
Citation
Trueb, B., Neuhauss, S.C., Baertschi, S., Rieckmann, T., Schild, C., and Taeschler, S. (2005) Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor. BBA Gene Structure and Expression. 1727(1):65-74.
Abstract
FGFRL1 is a novel FGF receptor that lacks the intracellular tyrosine kinase domain. While mammals, including man and mouse, possess a single copy of the FGFRL1 gene, fish have at least two copies, fgfrl1a and fgfrl1b. In zebrafish, both genes are located on chromosome 14, separated by about 10 cM. The two genes show a similar expression pattern in several zebrafish tissues, although the expression of fgfrl1b appears to be weaker than that of fgfrl1a. A clear difference is observed in the ovary of Fugu rubripes, which expresses fgfrl1a but not fgfrl1b. It is therefore possible that subfunctionalization has played a role in maintaining the two fgfrl1 genes during the evolution of fish. In human beings, the FGFRL1 gene is located on chromosome 4, adjacent to the SPON2, CTBP1 and MEAEA genes. These genes are also found adjacent to the fgfrl1a gene of Fugu, suggesting that FGFRL1, SPON2, CTBP1 and MEAEA were preserved as a coherent block during the evolution of Fugu and man.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping