ZFIN ID: ZDB-PUB-050119-3
Kidney Development and Disease in the Zebrafish
Drummond, I.A.
Date: 2005
Source: Journal of the American Society of Nephrology : JASN   16(2): 299-304 (Review)
Registered Authors: Drummond, Iain
Keywords: none
MeSH Terms:
  • Animals
  • Disease Models, Animal
  • Embryonic Structures/ultrastructure*
  • Genomics
  • Humans
  • Kidney/embryology*
  • Models, Animal
  • Nephrons/embryology*
  • Nephrons/ultrastructure
  • Organogenesis/physiology*
  • Polycystic Kidney Diseases/embryology
  • Polycystic Kidney Diseases/genetics*
  • Species Specificity
  • Zebrafish
PubMed: 15647335 Full text @ J. Am. Soc. Nephrol.
Unraveling the molecular pathogenesis of human disease presents many experimental challenges, not the least of which is that experiments on humans are generally frowned upon. Model organisms, including the zebrafish, allow for experimental analysis of gene function and the detailed characterization of disease processes. Zebrafish have matured as a vertebrate model organism now that genetic tools for targeted "knockdowns" and unbiased mutagenesis approaches are in hand. The fish larval pronephros is a relevant kidney in which to pursue many aspects of human kidney development and disease. This short review outlines recent progress in applying the zebrafish pronephros to issues of human health and development.