PUBLICATION

When sugars guide axons: insights from heparan sulphate proteoglycan mutants

Authors
Lee, J.S., and Chien, C.B.
ID
ZDB-PUB-041202-7
Date
2004
Source
Nature reviews. Genetics   5(12): 923-935 (Review)
Registered Authors
Chien, Chi-Bin, Lee, Jeong-Soo
Keywords
none
MeSH Terms
  • Animals
  • Axons/physiology*
  • Drosophila
  • Heparan Sulfate Proteoglycans/chemistry
  • Heparan Sulfate Proteoglycans/genetics
  • Heparan Sulfate Proteoglycans/physiology*
  • Ligands
  • Mice
  • Models, Biological
  • Mutation
  • Nematoda
  • Zebrafish
PubMed
15573124 Full text @ Nat. Rev. Genet.
Abstract
Although there have previously been hints that heparan sulphate proteoglycans (HSPGs) are important for axon guidance, as they are for many other biological processes, there has been little in vivo evidence for interaction with known axon-guidance pathways. Genetic analyses of fly, mouse, nematode and zebrafish mutants now confirm the role of HSPGs in axon guidance and are beginning to show that they might have a key role in modulating the action of axon-guidance ligands and receptors.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping