PUBLICATION
Investigating the morphology, function and genetics of cytotoxic cells in bony fish
- Authors
- Yoder, J.A.
- ID
- ZDB-PUB-041111-15
- Date
- 2004
- Source
- Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 138(3): 271-280 (Journal)
- Registered Authors
- Yoder, Jeffrey A.
- Keywords
- C-type lectin; Cytotoxicity; Cytotoxic T lymphocyte; Macrophage; Natural killer cell; Neutrophil; Non-specific cytotoxic cells; Novel immune-type receptors
- MeSH Terms
-
- Animals
- Cytotoxicity, Immunologic/immunology*
- Fishes/genetics*
- Fishes/immunology*
- Humans
- Killer Cells, Natural/cytology
- Killer Cells, Natural/immunology
- Killer Cells, Natural/metabolism
- Macrophages/cytology
- Macrophages/immunology
- Neutrophils/cytology
- Neutrophils/immunology
- T-Lymphocytes, Cytotoxic/cytology
- T-Lymphocytes, Cytotoxic/immunology
- PubMed
- 15533785 Full text @ Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Citation
Yoder, J.A. (2004) Investigating the morphology, function and genetics of cytotoxic cells in bony fish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 138(3):271-280.
Abstract
Bony fish (teleosts) possess multiple cytotoxic cell lineages that recognize and destroy virally infected and transformed cells. In general, these lineages parallel their functional equivalents in mammals and include neutrophilic granulocytes, macrophages, cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. These four cell types have been morphologically identified in multiple fish species but only limited information is available about their function. In contrast, much work has gone into examining the function of a fifth cytotoxic cell lineage, termed nonspecific cytotoxic cells (NCC), that has been referred to as the bony fish equivalent of NK cells. However, evidence suggesting that NCC do not represent the NK lineage has come through the development of multiple cytotoxic catfish cell lines that are morphologically and functionally similar to human NK cells and are distinct from NCC. In addition to characterizing cytotoxic cells from fish, recent work has identified the novel immune-type receptors (NITR) and cichlid killer leukocyte receptors (cKLR) that are structurally related to mammalian NK receptors and likely play a role in cytotoxic function in fish. This review summarizes the morphological and functional evidence for cytotoxic cells within bony fish and discusses future directions for examining cytotoxicity through genomics and transgenics.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping