PUBLICATION
A Zebrafish Model of Germ Cell Aneuploidy
- Authors
- Poss, K.D.
- ID
- ZDB-PUB-041008-6
- Date
- 2004
- Source
- Cell cycle (Georgetown, Tex.) 3(10): 1225-1226 (Other)
- Registered Authors
- Poss, Kenneth D.
- Keywords
- none
- MeSH Terms
-
- Aneuploidy*
- Animals
- Germ Cells/metabolism*
- Germ Cells/pathology*
- Models, Animal
- Zebrafish/genetics*
- PubMed
- 15467466 Full text @ Cell Cycle
Citation
Poss, K.D. (2004) A Zebrafish Model of Germ Cell Aneuploidy. Cell cycle (Georgetown, Tex.). 3(10):1225-1226.
Abstract
The high frequency of chromosomal nondisjunction in human germ cells impacts society in many ways. Yet, the etiology of chromosome disorders remains unclear. Using a zebrafish strain with a hypomorphic mutation in the kinase Mps1, a genetic association between reduced germ cell mitotic checkpoint activity and aneuploid progeny was recently established. This work highlights the exquisite sensitivity of vertebrate germ cells to disruptions in Mps1 function and mitotic checkpoint activity. In addition, it introduces the zebrafish as a promising tool with which to further investigate the origins of aneuploidy.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping