PUBLICATION
A star with stripes: zebrafish as an infection model
- Authors
- van der Sar, A.M., Appelmelk, B.J., Vandenbroucke-Grauls, C.M., and Bitter, W.
- ID
- ZDB-PUB-041004-3
- Date
- 2004
- Source
- Trends in microbiology 12(10): 451-457 (Review)
- Registered Authors
- Bitter, Wilbert
- Keywords
- none
- MeSH Terms
-
- Animals
- Bacterial Infections*
- Disease Models, Animal*
- Embryonic Development/physiology
- Fish Diseases/microbiology*
- Virus Diseases*
- Zebrafish/genetics
- Zebrafish/immunology
- Zebrafish/physiology*
- PubMed
- 15381194 Full text @ Trends Microbiol.
Citation
van der Sar, A.M., Appelmelk, B.J., Vandenbroucke-Grauls, C.M., and Bitter, W. (2004) A star with stripes: zebrafish as an infection model. Trends in microbiology. 12(10):451-457.
Abstract
The zebrafish, one of the favourite animals of developmental biologists, is rapidly gaining ground in infection models. Various experimental infection models have been set up to study both human and fish pathogens in more detail. The most interesting of these pathogens is perhaps Mycobacterium marinum, a close relative of Mycobacterium tuberculosis, and causes fish tuberculosis. With the zebrafish, genetic screens in a vertebrate host with a fully developed immune system are possible. In addition, bacterial infections can be analysed in real-time in zebrafish embryos. Here, we discuss the use of the zebrafish as a host for studying infectious diseases, and also the challenges, benefits and hurdles associated with using this model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping