L1.1 is involved in spinal cord regeneration in adult zebrafish
- Becker, C.G., Lieberoth, B.C., Morellini, F., Feldner, J., Becker, T., and Schachner, M.
- The Journal of neuroscience : the official journal of the Society for Neuroscience 24(36): 7837-7842 (Journal)
- Registered Authors
- Becker, Catherina G., Becker, Thomas, Feldner, Julia, Lieberoth, Bettina, Schachner, Melitta
- regeneration; cell recognition molecule; spinal cord; brainstem; teleost; Danio rerio
- MeSH Terms
- Brain Stem/physiopathology
- Drug Implants
- Gelatin Sponge, Absorbable
- Nerve Regeneration/drug effects
- Nerve Regeneration/physiology*
- Recovery of Function
- Single-Blind Method
- Spinal Cord/physiology*
- Spinal Cord Injuries/physiopathology*
- 15356195 Full text @ J. Neurosci.
Becker, C.G., Lieberoth, B.C., Morellini, F., Feldner, J., Becker, T., and Schachner, M. (2004) L1.1 is involved in spinal cord regeneration in adult zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(36):7837-7842.
Adult zebrafish, in contrast to mammals, regrow axons descending from the brainstem after spinal cord transection. L1.1, a homolog of the mammalian recognition molecule L1, is upregulated by brainstem neurons during axon regrowth. However, its functional relevance for regeneration is unclear. Here, we show with a novel morpholino-based approach that reducing L1.1 protein expression leads to impaired locomotor recovery as well as reduced regrowth and synapse formation of axons of supraspinal origin after spinal cord transection. This indicates that L1.1 contributes to successful regrowth of axons from the brainstem and locomotor recovery after spinal cord transection in adult zebrafish.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes