PUBLICATION
Guanylate cyclase-activating proteins: structure, function, and diversity
- Authors
- Palczewski, K., Sokal, I., and Baehr, W.
- ID
- ZDB-PUB-040908-4
- Date
- 2004
- Source
- Biochemical and Biophysical Research Communications 322(4): 1123-1130 (Journal)
- Registered Authors
- Keywords
- Guanylate cyclase; Guanylate cyclase-activating proteins; Phototransduction; Ca2+-binding proteins; Rod and cone photoreceptors
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Calcium-Binding Proteins/chemistry*
- Calcium-Binding Proteins/genetics
- Calcium-Binding Proteins/physiology*
- Guanylate Cyclase-Activating Proteins
- Humans
- Mice
- Models, Animal
- Molecular Sequence Data
- Phylogeny
- Pineal Gland/chemistry
- Protein Processing, Post-Translational
- Retina/chemistry
- Retinal Diseases/genetics
- Zebrafish Proteins
- PubMed
- 15336959 Full text @ Biochem. Biophys. Res. Commun.
Citation
Palczewski, K., Sokal, I., and Baehr, W. (2004) Guanylate cyclase-activating proteins: structure, function, and diversity. Biochemical and Biophysical Research Communications. 322(4):1123-1130.
Abstract
The guanylate cyclase-activating proteins (GCAPs), Ca(2+)-binding proteins of the calmodulin gene superfamily, function as regulators of photoreceptor guanylate cyclases. In contrast to calmodulin, which is active in the Ca(2+)-bound form, GCAPs stimulate GCs in the [Ca(2+)]-free form and inhibit GCs upon Ca(2+) binding. In vertebrate retinas, at least two GCAP1 and two GCs are present, a third GCAP3 is expressed in humans and fish, and at least five additional GCAP4-8 genes have been identified or are predicted in zebrafish and pufferfish. Missense mutations in GCAP1 (Y99C, I143NT, E155G, and P50L) have been associated with autosomal dominant cone dystrophy. Absence of GCAP1/2 in mice delays recovery of the photoresponse, a phenotype consistent with delay in cGMP synthesis. In the absence of GCAP2, GCAP1 supports the generation of wild-type flash responses in both rod and cone cells. Recent progress revealed an unexpected complexity of the GC-GCAP system, pointing, out a number of unsolved questions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping