PUBLICATION
Understanding endothelin-1 function during craniofacial development in the mouse and zebrafish
- Authors
- Clouthier, D.E., and Schilling, T.F.
- ID
- ZDB-PUB-040726-8
- Date
- 2004
- Source
- Birth defects research. Part C, Embryo today : reviews 72(2): 190-199 (Review)
- Registered Authors
- Schilling, Tom
- Keywords
- Danio rerio, neural crest, dHAND/HAND2, Ednra, Ednl, branchial arch
- MeSH Terms
-
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Body Patterning
- Branchial Region/metabolism
- DNA-Binding Proteins/metabolism
- Endothelin-1/metabolism
- Endothelin-1/physiology*
- Gene Expression Regulation
- Gene Expression Regulation, Developmental*
- Jaw/embryology
- Mice
- Models, Biological
- Mutation
- Neural Crest/embryology*
- Pharynx/embryology
- Receptor, Endothelin A/metabolism
- Signal Transduction
- Time Factors
- Transcription Factors/metabolism
- Zebrafish
- Zebrafish Proteins
- PubMed
- 15269892 Full text @ Birth Defects Res. C Embryo Today
Citation
Clouthier, D.E., and Schilling, T.F. (2004) Understanding endothelin-1 function during craniofacial development in the mouse and zebrafish. Birth defects research. Part C, Embryo today : reviews. 72(2):190-199.
Abstract
Morphogenesis of the face and neck is driven by an intricate relay of signaling molecules and transcription factors organized into hierarchical pathways. The coordinated action of these pathways regulates the development of neural crest cells within the pharyngeal arches, resulting in proper spatiotemporal formation of bone, cartilage, and connective tissue. While the functions of many genes involved in these processes were initially elucidated through the use of knockout technology in the mouse, increasing numbers of zebrafish craniofacial mutants have led to a rapid expansion in the identification of genes involved in craniofacial development. A comparative analysis of signaling pathways involved in these processes between mouse and zebrafish holds the potential not only to pinpoint conserved and therefore crucial gene functions in craniofacial development, but also to rapidly identify and study downstream effectors. These complementary approaches will also allow rapid identification of candidate genes and gene functions disrupted in human craniofacial dysmorphologies. In this brief review, we present a comparative analysis of one molecule involved in craniofacial development, endothelin-1, a small, secreted protein that is crucial for patterning the neural crest cells that give rise to lower jaw and throat structures. Birth Defects Research (Part C) 72:190-199, 2004. Copyright 2004 Wiley-Liss, Inc.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping