|ZFIN ID: ZDB-PUB-040721-3|
Exploring alternative models of rostral-caudal patterning in the zebrafish neurectoderm with computer simulations
Chitnis, A.B., and Itoh, M.
|Source:||Current opinion in genetics & development 14(4): 415-421 (Review)|
|Registered Authors:||Chitnis, Ajay, Itoh, Motoyuki|
|Keywords:||ADMP, anti-dorsalizing morphogenetic protein, AP, anterior–posterior, BMP, bone morphogenetic protein, DV, dorsal–ventral, FGF, fibroblast growth factor, hdl, headless, MHB, midbrain–hindbrain boundary, MZ, maternal zygotic, oep, one eyed pinhead, TCF3, T-cell Factor 3, tcf3b MO, T-cell Factor 3b morpholinos, Wt, wild-type|
|PubMed:||15261658 Full text @ Curr. Opin. Genet. Dev.|
Chitnis, A.B., and Itoh, M. (2004) Exploring alternative models of rostral-caudal patterning in the zebrafish neurectoderm with computer simulations. Current opinion in genetics & development. 14(4):415-421.
ABSTRACTThe StarLogo and NetLogo programming environments allow developmental biologists to build computer models of cell–cell interactions in an epithelium and visualize emergent properties of hypothetical genetic regulatory networks operating in the cells. These environments were used to explore alternative models that show how a posteriorizing morphogen gradient might define gene-expression domains along the rostral–caudal axis in the zebrafish neurectoderm. The models illustrate how a hypothetical genetic network based on auto-activation and cross-repression could lead to establishment of discrete non-overlapping gene-expression domains.
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