|ZFIN ID: ZDB-PUB-040719-7|
Expression of zebrafish six1 during sensory organ development and myogenesis
Bessarab, D.A., Chong, S.W., and Korzh, V.
|Source:||Developmental dynamics : an official publication of the American Association of Anatomists 230(4): 781-786 (Journal)|
|Registered Authors:||Bessarab, Dmitry, Chong, Shang Wei, Korzh, Vladimir|
|Keywords:||placode, otic vesicle, lateral line, inner ear, somite, cranial muscles, branchial arch, pituitary, mind bomb|
|PubMed:||15254912 Full text @ Dev. Dyn.|
Bessarab, D.A., Chong, S.W., and Korzh, V. (2004) Expression of zebrafish six1 during sensory organ development and myogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 230(4):781-786.
ABSTRACTDrosophila sine oculis homologous genes in vertebrates are homeobox-containing transcription factors functioning within the Pax-Six-Eya-Dach regulatory network during development. In this study, we describe the cloning and expression of a zebrafish homolog of sine oculis, six1. The reverse transcription-polymerase chain reaction demonstrated accumulation of six1 transcripts at mid-gastrula, and in situ hybridization showed their subsequent expression in the cranial placode and later in the olfactory, otic, and lateral line placodes, inner ear, and neuromasts. In addition, six1 is expressed in the pituitary, branchial arches, somites, pectoral fin, ventral abdomen muscle, and the cranial muscles of the eye and lower jaw. An increase of six1 expression was observed in the lateral line, muscles, and inner ear of the mind bomb mutant, illustrating a regulatory effect of the Notch pathway on expression of Six genes. Developmental Dynamics 230:781-786, 2004 Copyright 2004 Wiley-Liss, Inc.